PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
نویسندگان
چکیده
In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic "interval timer" created by PERIOD-TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedback into a full circadian model produced results that are consistent with previous experimental observations of wild-type protein profiles and numerous mutant phenotypes.
منابع مشابه
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عنوان ژورنال:
- PLoS Computational Biology
دوره 3 شماره
صفحات -
تاریخ انتشار 2007